Full title
Authors
Lajos Zsom, Marianna Zsom, Tibor Fülöp, Catherine Wells, Michael F. Flessner, József Eller, Charlotta Wollheim, Jörgen Hegbrant, Giovanni F. M. Strippoli
Abstract
The relationship between treatment time, ultrafiltration rate (UFR) and inflammation has received limited exploration so far. This is a cross-sectional cohort study of 12 hemodialysis clinics. Statistical models explored the association of multiple patient- and dialysis-specific covariates with low albumin (5 mg/dl) and calculated the ORs and 95% CIs. 616 patients with a mean age of 60.9 +/- 14.4 years participated in our study. Mean treatment time was 237.3 +/- 23.8 min and mean UFR was 7.0 +/- 4.0 ml/kg/h. In stepwise logistic regression, treatment time >4 h reduced the risk of low albumin (OR 0.397, 95% CI 0.235-0.672, p < 0.001). Congestive heart failure (OR 1.634, 95% CI 1.154-2.312, p = 0.006) and acute infection (OR 1.799, 95% CI 1.059-3.056, p = 0.03) were significant correlates of the risk of high CRP. There was no association between UFR and either CRP or albumin. Treatment time had a significant cross-sectional association with serum albumin but not with CRP.
